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EVALUATION OF FELINE IMMUNODEFICIENCY VIRUS ORF-A MUTANTS AS CANDIDATE ATTENUATED VACCINE

机译：候选弱毒疫苗对猫免疫缺陷病毒ORF-A突变体的评估

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Feline immunodeficiency virus (FIV) made defective in the accessory gene ORF-A were previously shown to be greatly attenuated in its ability to replicate in lymphocytes but to grow normally or near normally in other cell types. Here, we examined whether FIV thus mutated could protect specific pathogen-free cats against challenge with ex vivo fully virulent homologous virus. No reversion of the vaccinating infections to wild type ORF-A was noted over 22 months of in vivo infection. Following challenge, 6/6 unvaccinated control cats became readily and heavily infected. In contrast, 3/9 vaccinees showed no evidence of the challenge virus over a 15-month observation period. In the other vaccinees, the challenge virus was predominant for various periods of time, but pre-existing viral loads and CD4 lymphocyte counts were either unaffected or altered only marginally and transiently. These findings show that ORF-A-defective FIV should be further examined as a candidate live attenuated vaccine. (C) 2004 Elsevier Inc. All rights reserved.
机译：先前显示在辅助基因ORF-A中有缺陷的猫免疫缺陷病毒（FIV）在淋巴细胞中复制的能力大大减弱，但在其他细胞类型中正常或接近正常生长。在这里，我们检查了这样突变的FIV是否可以保护特定的无病原猫免受体外全毒力同源病毒的攻击。在体内感染的22个月中，未发现接种疫苗的感染恢复为野生型ORF-A。攻击后，6/6未接种疫苗的对照猫变得容易受到严重感染。相反，在15个月的观察期内，3/9疫苗接种者未显示出挑战病毒的迹象。在其他疫苗中，挑战病毒在不同时期均占主导地位，但既存病毒载量和CD4淋巴细胞计数未受影响或仅在边缘和瞬时发生了变化。这些发现表明，ORF-A缺陷型FIV应作为减毒活疫苗的候选者进行进一步检查。 （C）2004 Elsevier Inc.保留所有权利。

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